When it comes to weight loss, many people turn to fat burner supplements for help. Fat burning supplements and pills are designed to boost metabolism, increase energy levels, and suppress appetite. They may also provide other benefits that make it easier to lose weight. However, not all fat burners are safe or effective.
In this article, we will take a look at several of the safest fat burner supplements available to buy over-the-counter (OTC) and online. In addition to helping you choose a safe and effective fat burner, we will also take a look at how fat burners work and provide information that will help you optimize the overall benefits this type of dietary supplement provides.
Top 5 Safe Fat Burning Supplements – A Quick Look
In addition to being safe and effective fat-burning supplements, these five options are manufactured and distributed by reputable companies that provide their customers with money-back guarantees.
The Best Safe Fat Burners Evaluated and Compared
These are the safest over the counter supplements that burn fat. They can used for weight loss or for excess fat cutting and fat loss.
#1 – PhenQ – Best Fat Burner for General Weight Loss
PhenQ is a multi-action supplement – one of the best “all-rounders” you can buy. It has been available for quite some time and many people consider it their go-to option when they want to lose weight quickly and safely.
Each bottle contains 60 pills which equate to a month’s supply. The large serving size ensures users get plenty of active ingredients.
It’s important to note that the product was formulated for men and women alike. This makes it a great choice for couples who are trying to lose weight together, but it’s also an excellent option for individuals who want to burn stubborn fat quickly without the repercussions of side effects.
Due to the extensive level of support it provides, we consider PhenQ to be the best fat burner supplement for most people who want to lose weight safely.
Key Benefits of PhenQ
Although the manufacturer does not mention this, one of the ingredients in PhenQ has clinically proven value as a fat blocker.
Fat blockers inhibit fat digestion. By doing this they limit the amount of calories your body gets from dietary fats.
PhenQ Ingredient Highlights
The PhenQ weight fat-burning formula consists of 13 ingredients. It’s a sophisticated blend of nutrients and plant extracts. There are no chemicals or drugs in PhenQ. PhenQ is often positioned as a natural Phentermine alternative due to its strength and impeccable safety record.
Furthermore, PhenQ weight loss pills are also non-GMO and 100% vegan-friendly. Notable ingredients include nopal, capsicum, chromium, and natural caffeine.
PhenQ is also renowned for being the only diet pill that contains a-Lacys Reset. This exciting proprietary ingredient combines an amino acid with a powerful antioxidant. It’s a unique compound that’s been shown to deliver serious improvements in fat loss.
Nopal (Opuntia ficus-indica) is a species of cactus that provides energy-boosting amino acids and is a good source of fiber. Although it has a long history of use as an appetite suppressant, research shows it has additional values in other areas.
Clinical investigation shows nopal enhances metabolism by promoting the development of certain probiotic bacteria species in the gut and also works as a fat blocker. [2, 3]
Nopal may be versatile but capsicum tops its abilities. Research shows the capsaicin it provides increases metabolism via thermogenesis, suppresses hunger, improves fat oxidation, and inhibits adipogenesis. In common with nopal, it also produces positive changes in the gut microbiota. 
Instead of using a standard capsicum extract, the company that makes PhenQ is using Capsimax. It’s a high-quality patented ingredient that is designed to be extremely potent while also being gentle on the stomach.
Chromium is a mineral that regulates blood sugar and insulin. PhenQ provides it as chromium picolinate. This is another good choice on the part of the manufacturer because the body absorbs this ingredient very easily.
One of the interesting things about chromium picolinate is that, in addition to providing significant weight reductions, it also appears to target visceral fat (belly fat). 
Caffeine is an energy booster that’s good for fighting fatigue. It also supports improvements in mental clarity. Most people know these things already. However, the fact that caffeine has scientifically proven credentials as a thermogenic fat burner may not be common knowledge. 
PhenQ Fat Burner Buying Info
PhenQ is only available via the official website. You cannot buy it elsewhere. However, the manufacturer offers free rapid shipping and a 60-day money-back guarantee.
Although PhenQ contains caffeine, the dose is not overly high so, unless you are unusually sensitive to stimulants, there will be no need to worry about jitters or other side effects. Each dose of PhenQ provides no more caffeine than a single shot of espresso coffee.
#2 – Capsiplex – Fat Burner for Men and Women
Capsiplex is another well-known option but its formulation is not as extensive as PhenQ. Nonetheless, it’s a potent weight loss aid that targets fat burning.
Capsiplex has received much attention since it first became available in the late 2000s. Today, it remains one of the most popular diet pills on the market but is now available in two forms.
Capsiplex Burn is formulated especially for men, while Capsiplex Trim is a fat burner for women. Both versions provide the same benefits but contain different dosages of ingredients that have been carefully chosen to work best for each gender.
Capsiplex is a highly respected brand and the company has presented a wealth of information about how it works, including clinical data. It’s not often you get this kind of transparency from a supplement manufacturer.
Key Benefits of Capsiplex
Suppresses appetite and cravings
Boosts metabolism and fat-burning
Supports the development of lean muscle mass
Unlike PhenQ, Capasiplex is designed for men and women who have a strong desire to train. Both formulations will still help you to burn fat if you don’t but, if training is more of an obligation than a passion, you will be better off choosing PhenQ.
Capsiplex Ingredient Highlights
The main ingredient in Capsiplex is capsicum extract. It provides twice as much as PhenQ but uses a standard capsicum extract instead of Capimax.
Caffeine is another key ingredient in Capsiplex and, again the dose is higher than you would get from using PhenQ.
Capsiplex Trim provides twice as much caffeine as PhenQ and Burn provides 50 mg more. This is largely to support improvements in training capacity.
However, neither formulation provides caffeine in an overly high dose. Men using burn will get slightly less caffeine per dose than they would get from consuming a treble espresso.
With formulas that are more geared towards speeding up metabolism than controlling hunger, the two Capsiplex supplements also provide green tea and green coffee bean extract.
Green tea extract is an ingredient that’s present in many diet pills. It’s a popular ingredient. That’s not surprising. Data from numerous clinical trials proves its abilities as a thermogenic fat burner and anti-obesity compound and also suggests it may lower the risk of cardiovascular disease. 
Another ingredient of notable value, green coffee bean extract provides chlorogenic acid.
Chlorogenic acid aids weight loss by reducing the absorption of energy from carbohydrates. Some research suggests that, in addition to supporting weight loss, chlorogenic acid may actually be able to target visceral fat (belly fat). 
Capsiplex Order Info
Capsiplex is available online only and the manufacturer provides free shipping. Similar to PhenQ, it also offers a 60-day money-back guarantee.
Both versions of the supplement are suitable for vegans and vegetarians.
The somewhat higher caffeine content may put some dieters off but will most likely be a welcome bonus for men and women wishing to increase their level of intensity during exercise.
#3 – Leanbean – Safe Fat Burner for Women
Leanbean is a fat burner that’s “designed for women by women.” It contains a blend of ingredients that help to suppress hunger, boost metabolism, and support energy levels. However, this option places more emphasis on hunger control because women have been shown to be more susceptible to hunger than men.
Like PhenQ and Capsiplex, Leanbean is a vegan-friendly fat burner. These days, most of the top dietary supplements are, and that’s great. This makes them suitable for a wider variety of users.
One of the biggest differences between Leanbean and most other weight loss pills is the formula does not have any caffeine in it. In fact, it has no added stimulants at all. It boosts energy and fights fatigue via alternative ingredients instead.
Key Benefits of Leanbean
Reduces tiredness and fatigue
Suppresses hunger and cravings
Supports improvements in metabolism and fat-burning
Leanbean Ingredient Highlights
By now you are probably wondering how Leanbean can boost energy levels without caffeine or the help of alternative stimulants.
You may be surprised to learn that the formula contains several ingredients that can do this. The two most important ones are vitamin B6 and vitamin B12. Both these vital water-soluble vitamins are common ingredients in energy drinks and sports supplements.
Both vitamins serve a variety of other roles in the body as well. Emerging research suggests they may also influence enzyme activity in ways that result in increases in metabolism and fat loss. 
Much of Leanbean’s value as a fat burner is due to choline. However, other ingredients, such as acai berry extract help in this area as well.
Choline is a vitamin-like compound that plays an important role in good health. Research involving female martial artists shows that, when taken daily, supplements that provide choline can deliver significant improvements in weight loss. 
We previously mentioned Leanbean’s prowess as an appetite suppressant. This is largely due to a generous dose of konjac root. Also known as glucomannan, this ingredient is so absorbent it can soak up 50 times its weight in water. When this happens in the stomach, the water-soluble fiber swells considerably, causing a feeling of fullness.
Research shows glucomannan supplements provide the best results when they provide a full gram of root fiber, three times per day. 
Leanbean ticks all the right boxes in this regard and the usage guidelines ensure Leanbean users take the supplement with enough water to ensure efficient hydration. 
Where to Buy Leanbean
Leanbean is only available via the official website.
In common with the other fat burners that rank highly for efficacy and safety, the manufacturer offers a money-back guarantee. However, you need to order a 3-month supply to get its protection.
When you order three bottles, you also get an extra bottle free of charge and, at 90 days, the guarantee period is surprisingly long. This option is called “The Complete Bundle” and will get you a free e-book download that contains the food secrets of a fitness model.
#4 – Prime Shred – Safest Fat Burner for Men for Cutting
Prime Shred is a thermogenic fat burner made in the USA. It’s primarily aimed at men but contains ingredients that can speed up women’s weight loss efforts too.
Like Capsiplex Burn, Prime Shred is aimed at athletic men who like to spend a lot of time training in a gym or doing sports. The average guy who needs a supplement to get rid of his excess body fat will be better off choosing PhenQ because it provides a greater level of overall weight loss support.
Guys who are seeking a supplement to help them shed excess body fat and train harder, while also improving their muscle definition, may want to choose Capsiplex Burn over Prime Shred. It’s a slightly better option but there’s not a great deal of difference between the two supplements. They are both safe, effective, non-GMO, and vegan-friendly.
Key Benefits of Prime Shred
Helps you to burn fat
Targets fat in stubborn areas
Helps you to push through plateaus
Helps you to get ripped and lean
Prime Shred Ingredient Highlights
In common with Capsiplex, Prime Shred provides extracts taken from green coffee beans and green tea. The formula also contains caffeine but the dose is 12.5% higher than that provided by Capsiplex Burn. We’re still not looking at a stimulant-driven fat burner but Prime Shred will be a poor choice for anyone who gets the jitters after drinking coffee.
Cayenne pepper is another one of the key fat burners in Prime Shred. Like capsicum peppers, it’s an excellent natural source of capsaicin and the benefits it provides are the same. 
Rhodiola rosea is a Prime Shred ingredient you may not be familiar with. It’s a popular adaptogen herb that offers protection from stress.
If your efforts to improve your physique tend to bring anxiety into your life, due to the presence of Rhodiola rosea Prime Shred may be the best fat burner to choose. Research shows this herb may also have the potential to prevent burnout. 
Where to Order Prime Shred
Although we prefer Capsiplex Burn overall, Prime Shred has a longer money-back guarantee. At 100 days, it’s even longer than the Leanbean guarantee and you don’t have to buy more than one bottle to get it.
However, like all the other supplements so far, you can forget about finding a local supplier, you can only buy Prime Shred via the official website.
#5 – Clenbutrol – Safe Cutting Fat Burner
Popular with both sexes, Clenbutrol is a natural supplement that’s extremely good at burning fat without causing side effects. It’s also got a reputation for being a Hollywood weight loss secret.
Of course, there is no way to know if stars such as Hugh Jackman and Vin Diesel rely on it to help them get “cut” (in a good way) before any of their movies. If they do, they’re not going to admit it.
Nevertheless, plenty of people who have lower profile lifestyles are happy to admit they use Clenbutrol and state the supplement provides them with excellent results. This premium fat burner is easily one of the best options for men and women who want to cut their excess fat without any of the side effects, such as cholesterol imbalance and high blood pressure, that are common responses to fat-burning drugs.
Key Clenbutrol Benefits
Clenbutrol Ingredient Highlights
Like a lot of fat burners, Clenbutrol provides caffeine. However, the caffeine in the formula comes from guarana berry extract. Guarana is different from most other natural sources of caffeine because it releases the stimulant into the body slowly. This results in longer-lasting improvements in energy, mental focus, and thermogenic fat burning.
The Clenbutrol formula also contains Vitamin B3, bitter orange, and garcinia cambogia,
Also known as niacin, Vitamin B3 improves vasodilation. This slight expansion of the blood vessels can improve exercise capacity by helping the muscles get a better supply of blood.
In common with vitamins B6 and B12, vitamin B3 appears to trigger changes in enzyme activity that enhance metabolism and fat loss. 
Bitter orange is the common name for Citrus aurantium. This orange species provides synephrine. It’s a stimulant that supports weight loss and improvements in exercise capacity by increasing thermogenesis and vitality.
Research suggests synephrine supplements may be particularly good for shedding excess body fat during periods of exercise. 
Garcinia cambogia is a tropical fruit. Its rind provides a plant compound called hydroxycitric acid (HCA).
HCA supports safe fat loss in several ways. It’s been shown to be good for controlling hunger and boosting metabolism. Like the chromium picolinate in PhenQ and the chlorogenic acid in Capsiplex and Prime Shred, HCA appears to be one of the best natural fat burners for reducing visceral fat. 
Clenbutrol Buying Guide
By now, you may not be surprised to discover Clenbutrol is only available from the manufacturer’s website or that it has a 60-day money-back guarantee.
This option is a little different from the previous ones because it was originally developed to provide athletes who are cutting with a safe alternative to a popular bodybuilding drug.
The drug is called Clenbuterol. It’s FDA-approved but only as a veterinary medication. The drug’s name ends in “uterol,” but the supplement name ends in “utrol.” It’s only a one-letter difference but it’s important not to confuse them. Although Clenbutrol is a safe fat burner to use, the drug it’s designed to replace is not.
What are Fat Burning Supplements and How Do They Work?
Fat-burning supplements are very popular with people who want to lose weight faster and/or avoid common obstacles such as hunger and diet-related fatigue.
More often than not produced in pill form, these over-the-counter supplements are designed to support the body’s natural fat-burning processes and help accelerate daily calorie expenditure.
The primary mechanism of action generally focuses on three key aspects:
1 – Boosting Metabolism
All fat-burning supplements contain ingredients that boost metabolism. More often than not they do this by increasing thermogenesis. This is a natural process that generates heat within the body.
By stimulating increases in metabolism, the supplements cause higher calorie expenditure, even when the body is resting. This means that your body will burn extra calories throughout the day, potentially resulting in greater fat loss over time.
However, good results will still require a suitable commitment to low-calorie dieting. It doesn’t matter how many extra calories you burn each day if you are constantly topping the levels up.
2- Suppressing Appetite
Most, but not all, fat-burning supplements contain ingredients that reduce cravings and suppress appetite. By keeping hunger at bay, these supplements make it much easier to commit to the dietary restrictions that are essential for effective weight loss.
3 – Improvements in Body Fat Utilization
Some fat-burner supplements provide ingredients that enhance the body’s ability to utilize its fat stores as an energy source. By improving lipolysis and promoting more efficient fat oxidation, these supplements increase the level of fatty acids and glycerol available to the body to fuel its biophysical activities.
Certain fat burners may also provide additional benefits that make it easier for people to reach and maintain their personal body goals such as regulating blood glucose levels or blocking the absorption of dietary fats.
Advanced options may also trigger positive changes in the gut microbiome or inhibit adipogenesis (fat storage).
However, despite the various ways supplements can support fat burning and weight loss, it’s important to remember none of them is a substitute for a healthy lifestyle. They are best seen as supportive tools that can tweak your biological machinery to help you lose weight more efficiently than you could possibly do with diet and exercise alone.
What are the Safest Fat Burning Ingredients to Look for?
Here are 10 ingredients to look for in a safe and effective fat burner supplement.
Caffeine – Stimulant that can boost metabolism and increase fat burning. Look for reasonable doses of 100-200mg.
Green tea extract – Contains EGCG catechins that induce thermogenesis and support fat oxidation. Opt for standardized extracts.
Glucomannan – A soluble dietary fiber that promotes fullness and reduces calorie intake. Dosages of 2-4g work well.
Chromium – An essential mineral that helps regulate insulin and can support fat loss. Chromium picolinate is highly bioavailable.
Choline – This nutrient plays a key role in fat metabolism in the liver. Choline bitartrate is a common form.
ForsLean (Coleus forskohlii) – Shown to potentially increase metabolic rate and boost fat burning through its active compound forskolin.
Cayenne pepper – Contains capsaicin that may have thermogenic properties and reduce appetite. Look for cayenne standardized to capsaicin.
Green coffee bean extract – Chlorogenic acids may inhibit fat absorption and increase fat metabolism. Opt for 45-50% chlorogenic acids.
Conjugated linoleic acid (CLA) – Research shows this fatty acid can reduce body fat gains and enhance fat loss. 1-2g daily is common.
5-HTP – Precursor to serotonin that may support appetite control. Doses of 100-300mg are used.
Caffeine In Weight Loss Supplements: What You Need to Know
There is a reason why most of the best weight loss supplements contain caffeine. It’s because it works.
According to research published in the American Journal of Clinical Nutrition, caffeine can boost metabolism by anywhere from 3-11%.
However, as is often the case with weight loss supplement ingredients, there are different ways to approach dosing and the amount provided can be important.
Caffeine is a potent stimulant, and the effects it provides can vary from person to person.
People who are sensitive to caffeine may experience jitters or other unpleasant side effects when taking supplements that contain large doses of caffeine.
For this reason, many supplements opt for a more moderate dose, such as 100-200 mg per serving. This amount is usually enough to provide the benefits of caffeine without causing adverse effects.
However, although most reputable manufacturers use caffeine sensibly, there are plenty of others that do not. Overly high doses of caffeine, or alternative stimulants, are often the reasons for supplements causing side effects.
It’s generally unwise to consume more than 400 mg of caffeine per day – from all sources. Some supplements provide close to this in a single dose, hitting the body with it all at once.
When people have bad experiences with caffeine-driven supplements like these, it causes caffeine to get a bad reputation. The truth is, when consumed in low to moderate doses caffeine is only going to be beneficial for most people. It’s not the ingredient that’s at fault, it’s the manufacturers that abuse it.
Safety Considerations for Fat-Burning Supplements
When you decide to use a fat-burning supplement and want to avoid side effects or other health risks, the first step is to choose a quality supplement from a reputable supplier. This article provides five excellent choices.
However, it’s always a wise precaution to consult your doctor before using any supplement for the first time. They will be able to advise you if there may be any interactions between the ingredients and any medication you are taking.
Also, remember to stick to the manufacturer’s recommended dose. Taking more will not necessarily improve your results but may increase the risk of side effects.
It’s also important to keep in mind that supplements are not a magic solution for weight loss. They should always be used in conjunction with a healthy diet and regular exercise routine.
If your supplement contains caffeine, it may be wise to limit your intake of caffeine from additional sources such as coffee or strong, black tea.
If you experience any adverse effects from using a fat-burning supplement, stop using it straight away and speak to your doctor if necessary.
Concluding Thoughts of Buying Safe Fat Burning Pills
Good fat burners can be useful tools that speed up your weight loss journey, help you avoid the bumps in the road, and get you to where you want to be more quickly.
However, you also want to arrive safely. This is obviously the route you want to take or you would have never taken the time to seek out an article such as this.
Throughout the article, we have concentrated on explaining the benefits the top options provide. We have also highlighted the value of the supplement ingredients and provided links to supportive research where necessary.
In closing, we’d like to offer some tips for getting the best value for money when ordering fat burners online. The manufacturers of all the safest fat burners provide extra bottles of pills, free of charge, when you order two or more bottles.
If you only need to lose a few pounds, the chances are one bottle will be enough. However, if you have a lot of weight to lose, deals such as these can help you to benefit from significant savings.
Sources of Reference
Biochemistry, Lipolysis: https://www.ncbi.nlm.nih.gov/books/NBK560564/
Physical and Dietary Intervention with Opuntia ficus-indica (Nopal) in Women with Obesity Improves Health Condition through Gut Microbiota Adjustment: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912383/
Effects of Cactus Fiber on the Excretion of Dietary Fat in Healthy Subjects: A Double Blind, Randomized, Placebo-Controlled, Crossover Clinical Investigation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109417
Dietary Capsaicin and Its Anti-obesity Potency: From Mechanism to Clinical Implications: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426284/
Chromium Picolinate Supplementation Attenuates Weight Gain and Increases Insulin Sensitivity in Subjects With Type 2 Diabetes: https://pubmed.ncbi.nlm.nih.gov/16873787/
Normal Caffeine Consumption: Influence on Thermogenesis and Daily Energy Expenditure in Lean and Postobese Human Volunteers: https://pubmed.ncbi.nlm.nih.gov/2912010/
Green Tea Extract Thermogenesis-Induced Weight Loss by Epigallocatechin Gallate Inhibition of Catechol-O-Methyltransferase: https://pubmed.ncbi.nlm.nih.gov/17201629/
Coffee Abundant in Chlorogenic Acids Reduces Abdominal Fat in Overweight Adults: A Randomized, Double-Blind, Controlled Trial: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683100/
B Vitamins Can Reduce Body Weight Gain by Increasing Metabolism-related Enzyme Activities in Rats Fed on a High-Fat Diet: https://pubmed.ncbi.nlm.nih.gov/30074168/
Effect of Choline Supplementation on Rapid Weight Loss and Biochemical Variables Among Female Taekwondo and Judo Athletes: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096089/
Scientific Opinion on the Substantiation of Health Claims Related to Konjac (Glucomannan) And Reduction of Body Weight: https://efsa.onlinelibrary.wiley.com/doi/pdf/10.2903/j.efsa.2010.1798
Multicenter, Open-Label, Exploratory Clinical Trial With Rhodiola Rosea Extract in Patients Suffering From Burnout Symptoms: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370380/
Acute P‐Synephrine Ingestion Increases Fat Oxidation Rate During Exercise: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972152/
Effects of Garcinia Cambogia (Hydroxycitric Acid) On Visceral Fat Accumulation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053034/